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This can occur when homologous X chromosomes fail to separate in the formation of the egg or sperm.Tetrasomy X is usually suspected based on symptoms present in the individual and is confirmed via karyotyping, which reveals the extra X chromosomes.Medical literature reports four tetra-X pregnancies, two healthy, one with trisomy 21, one stillborn with omphalocele.In terms of internal organ systems, tetrasomy X patients may have abnormal vision, hearing, circulatory systems, kidneys, or nervous systems.Christian Orthodox Archdeacon, Episcopal Archimandrite Architect Archpriest Ambassador, Goodwill Ambassador of one country to another country Ambassador of the U. Supreme Court Associate Justice of a State Supreme Court Astronaut Attorney Attorney General Attorney General, Assistant Attorney, U. Physically, tetrasomy X patients tend to have distinctive facial features such as epicanthal folds, flat nasal bridges, upslanting palpebral fissures, midface hypoplasia, small mouths, cleft or high arched palates, delayed or absent teeth, or enamel defects.The majority have also been reported as being longer and taller.

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In terms of hearing, patients are more prone to ear infections, sound blockage, or nerve abnormalities.

Traditionally, treatment for tetrasomy X has been management of the symptoms and support for learning.

Most girls are placed on estrogen treatment to induce breast development, arrest longitudinal growth, and stimulate bone formation to prevent osteoporosis.

Tetrasomy X was first described in 1961, and since then approximately 100 cases have been reported worldwide.

Approximately 60 affected females have been described in the medical literature.

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